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Signs & Symptoms

To track your symptoms over time, you can click on the toggle button next to each symptom description below or click on the Symptom Tracker icon.

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What are the signs and symptoms of CLL?

Signs and symptoms can help describe a medical issue. A sign is usually something that can be identified and measured, such a fever or pulse. A symptom is something that only you can identify and describe, such as pain or fatigue.

People with CLL often have no symptoms. The cause of a symptom may also be a different health issue other than leukemia. Often, people are diagnosed with CLL during a blood test done for another reason. Some people may experience the following symptoms or signs. Talk to your healthcare team, if you are experiencing any of these issues. It helps to track how long/often you’re experiencing these symptoms.

Swollen Lymph Nodes/Glands
People with CLL usually notice swelling of lymph nodes or glands in their neck, under their arms, or in the groin first.
Abdominal Fullness/Discomfort
Some people experience discomfort or fullness in their belly, which can be caused by an enlarged spleen and/or liver.
"B symptoms"
This includes fever, chills, night sweats, weight loss.
Recurrent Infections
People with CLL have a higher risk of infection because their immune system isn’t working as well. Infections can range from frequent colds or cold sores to pneumonia and other serious infections.
Shortness of Breath
Shortness of breath may be caused by anemia, but there may be other factors to discuss with your healthcare team.
Fatigue
Fatigue may be caused by anemia, stress, inactivity and/or other factors related to CLL.
Abnormal Blood Counts

Blood count abnormalities (red blood cells, white blood cells or platelets) is common in CLL and can be confirmed through a blood test. A few of these issues include:

  • Anemia: A low level of red blood cells can cause weakness, shortness of breath and/or dizziness.
  • Leukopenia: A low white blood cell count, which can increase risk of infections
  • Lymphocytosis: Excess lymphocytes can lead to a high white blood cell count
  • Thrombocytopenia: A low blood platelet count may lead to excess bruising, bleeding, frequent nosebleeds, and/or bleeding gums